Researches at UCSD Health Sciences identify gene with functional role in aging of eye
Published - 02/04/20 - 09:00 AM | 6239 views | 440 440 comments | 26 26 recommendations | email to a friend | print

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age. In a new paper, published online Jan. 14, 2020 in the journal Aging Cell, researchers at the University of California San Diego School of Medicine say the gene appears to play a key role in age-associated functional and anatomical aging in vivo in mouse retinas, a finding that has direct relevance to age-related eye diseases. 

Specifically, the research team, led by senior author Dorota Skowronska-Krawczyk, Ph.D., assistant professor in the Viterbi Family Department of Ophthalmology at UC San Diego Shiley Eye Institute, found that an age-related decrease in ELOVL2 gene expression was associated with increased DNA methylation of its promoter. Methylation is a simple biochemical process in which groups of carbon and hydrogen atoms are transferred from one substance to another. In the case of DNA, methylation of regulatory regions negatively impacts the expression of the gene. 

When researchers reversed hypermethylation in vivo, they boosted EVOVL2 expression and rescued age-related decline in visual function in mice. “These findings indicate that ELOVL2 actively regulates aging in mouse retina, provides a molecular link between polyunsaturated fatty acids elongation and visual functions, and suggests novel therapeutic strategies for treatment of age-related eye diseases,” wrote the authors.

ELOVL2 is involved in production of long-chain omega-3 and omega-6 polyunsaturated fatty acids, which are used in several crucial biological functions, such as energy production, inflammation response and maintenance of cell membrane integrity. The gene is found in humans as well as mice. 

In particular, ELOVL2 regulates levels of docosahexaenoic acid or DHA, a polyunsaturated omega-3 fatty acid abundantly found in the brain and retina. DHA is associated with a number of beneficial effects. Notably, its presence in photoreceptors in eyes promotes healthy retinal function, protects against damage from bright light or oxidative stress and has been linked to improving a variety of vision conditions, from age-related macular (AMD) degeneration to diabetic eye disease and dry eyes. 

Skowronska-Krawczyk said the work demonstrated for the first time that a “methylation clock” gene had a functional role in the aging of an organ. In this case, the eye. DNA methylation is used throughout the human body, essentially turning biological switches on and off to maximize efficient operation. It has key regulatory roles in the body’s cardiovascular, neurological, reproductive and detoxification systems. 

In recent years, there has been much work and progress in identifying possible biomarkers that predict the biological age (not chronological) of individuals. Such biomarkers would be useful in identifying risk and status of age-related diseases. ELOVL2 is among the genes attracting greatest interest.  

“I have been asked whether I think ELOVL2 is the aging gene,” said Skowronska-Krawczyk. “After thinking about it, it is not unreasonable to think that lower ELOVL2 expression might be at the basis for many age-related conditions. Future work in our lab will address that question.” 

For the full study, visit https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13100

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wanda davis
|
36 Minutes Ago
Its a great pleasure for me to write this testimony about how i got my Genital Herpes cured a month ago. i have been reading so many comments of some people who were cured from various diseases by Dr Aza but i never believed them. I was hurt and depressed so I was too curious and wanted to try DR. Aza then i contacted him through his email, he assured me 100% that he will heal me, i pleaded with him to help me out. My experience with him was great, he healed me just as he promised. he sent me his medication and ask me to go for a medical check up after two weeks of usage. i agreed with him i took this medication and went for a check up, to my greatest surprise my result was negative, i am really happy that i am cured and healthy again. I have waited for 3weeks to be very sure i was completely healed before writing this testimony. I did another blood test one week ago and it was still Herpes negative. so i guess its time i recommend anyone going through the same way. reach him through his email address: [email protected]  OR call, add him on Whatsapp  1(315) 795 1518      
Joy visa
|
June 04, 2020
I'm so exited to share my testimonies about the Good Work of Dr Adigba who get me cured from herpes simplex virus (HSV2) with his herbs, I never thought that I will live on earth before the year runs out. I have been suffering from herpes, I had spent a lot of money going from one Hospital to another looking for way to get rid of this disease, the hospital have been my home everyday residence. Constant checks up have been my hobby not until this faithful day, I was searching through the internet, I saw a testimony on how Dr Adigba helped someone in curing his herpes disease using his healing Herbs, quickly I copied his email just to give him a test I spoke to him, he told me that he is going to provide the herbal cure to me, which he did, after i receive his herbs and i take it as instructed i was cure permanently from herpes my herpes disease was gone. so I decided to share my testimony, that nothing is impossible with God, God use a man to healed me. No matter what you are passing through, no matter how deadly the sickness is and no matter what the situation is God that did mine is still going to do yours, people suffering from herpes, brain tumor, kidney disease, pcos, AIDS, ALS,copd, asthma, athritis,herpes, Cancer,Hpv, any kind of disease, you can rich him now via ? Gmail address: [email protected] or whatsapp 2348077875210....
daniella nelson
|
21 Hours Ago
I’m here to testify about what Dr purity did for me. I have been suffering from (GENITAL HERPES VIRUS) disease for the past 4 years and had constant pain and inching, especially in my private part. During the first year, I had faith in God that i would be cured someday.This disease started circulating all over my body and I have been taking treatment from my doctor, few weeks ago I came across a testimony of Rose Smith on the internet testifying about a Man called Dr purity on how he cured her from 7 years HSV 2. And she also gave the email address of this man, advise anybody to contact him for help on any kind of diseases that he would be of help, so I emailed him telling him about my (HSV 2) he told me not to worry that I was going to be cured!! Well, I never doubted him I have faith he can cure me too,, Dr purity prepared and sent me Healing Oil, Soap, roots and herbs which I took. In the first one week, I started experiencing changes all over me, after four weeks of using his Roots/ Herbs, Oil and Soap, I was totally cured. no more inching , pain on me anymore as Dr purity assured me. After some time I went to my doctor to do another test behold the result came out negative. So friends my advise is if you have such disease or know anyone who suffers from it or any other disease like HPV, HBV, HIV, ALS, HBP, CANCER etc. you can contact Dr.purity for help via [email protected] or whatsapp 2348102430456
karen kennedy
|
June 04, 2020
I'm here to testify about the great work Dr Aza did for me. I have been suffering from (HERPES) disease for the past 5 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called Dr Aza on how he cured her from Herpes Simplex Virus. And she also gave the email address of this man and advise anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! Well i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr Aza assured me that i will be cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can contact Dr Aza via email [email protected] You can also call or whatsApp his telephone number on 13157951518. Thanks once again Dr Aza.    
Joy visa
|
June 04, 2020
I'm so exited to share my testimonies about the Good Work of Dr Adigba who get me cured from herpes simplex virus (HSV2) with his herbs, I never thought that I will live on earth before the year runs out. I have been suffering from herpes, I had spent a lot of money going from one Hospital to another looking for way to get rid of this disease, the hospital have been my home everyday residence. Constant checks up have been my hobby not until this faithful day, I was searching through the internet, I saw a testimony on how Dr Adigba helped someone in curing his herpes disease using his healing Herbs, quickly I copied his email just to give him a test I spoke to him, he told me that he is going to provide the herbal cure to me, which he did, after i receive his herbs and i take it as instructed i was cure permanently from herpes my herpes disease was gone. so I decided to share my testimony, that nothing is impossible with God, God use a man to healed me. No matter what you are passing through, no matter how deadly the sickness is and no matter what the situation is God that did mine is still going to do yours, people suffering from herpes, brain tumor, kidney disease, pcos, AIDS, ALS,copd, asthma, athritis,herpes, Cancer,Hpv, any kind of disease, you can rich him now via ? Gmail address: [email protected] or whatsapp 2348077875210....
sidomarte
|
June 04, 2020
Can't still believe that i got cured from Genital Herpes through herbal treatment from Dr maggi who I met through the internet, I actually couldn't believe it at first because it sounded impossible to me knowing how far I have gone just to get rid of it. Dr maggi send me his medicine which I took as instructed and here I am living a happy life once again, a big thanks to Dr maggi, I am sure there are many herbal doctors out there but Dr maggi did it for me, contact him [email protected] , also call or whatsApp him on  1(917) 979-6387.
ALEXANDER
|
June 03, 2020
I'm Richiee, USA.It's been a while since I've

written to thank Dr Osagie who helped me in my

life. I was infected with HERPES SIMPLEX VIRUS in 2019 , i went to many

hospitals for cure but there was no solution, so I was thinking how can I

get a solution out so that my body can be okay. One day my Aunt Rosa

introduce me to Doctor Osagie having seen so many testimony online

about his herbal medication to cure HERPES and gave me his

email [email protected] OR

[email protected] , so i mail him. He told me all the

things I need to do and also give me instructions to follow, which I

followed properly. Before I knew what is happening after one weeks the

HERPES that was in my body got vanished. so if you are you are having

herpes or any kind of disease listed below

*DIABETES

*CANCER

*STROKE

*INFERTILITY

*HEART DISEASE

*HIV

*COLD SORES

*GENITAL WARTS*LUPOS VIRUS

And you also want cure, you can also email him at [email protected] OR

[email protected] or WHATSAPP 2347030465649
jame mary
|
June 03, 2020
All these post about HERBAL MEDICINE,are scarms and fake

trying to collect money all in the name of HERPES cure and when you contact them they will be asking for your name, pictures, country, phone number,

occupation and when you have given them all the information, they will be

asking for money. my name is jame mary,from Palm coast Florida U.S.A,

a woman of 56years I was once

suffering from herpes for good 3years and i spent a

lot of money going from one herbal doctor to another but they all scam and

take my money away until i told my friend the problems am facing in life he

quickly introduce me to this powerful herbal man called

Dr.ESEZOBOR who cured me from Herpes with his herbal medication , after

Doctor ESEZOBOR has finished preparing the herbal medicine, he asked me to

send him my residential address, so that he will send the herbal medicine

to me via D.H.L so i did. 2days later, i received the herbal medicine and i

had to follow the instructions he gave to me on how i will apply it. After

using if for a week and few days and I noticed that all the symptoms, pain,

itch and blisters are gone. 2weeks

later i went to hospital for test and according to the test done by the

Medical doctor called Marly it stated that i was herpes negative.

So viewers be wise and beware of fake people and fake herbal

doctors, they are all over the internet trying to steal from poor people. I

will drop the email of this powerful herbal doctor just in case you

want to contact him for help,WHATSAPP HIM ON 18327287363 or Email him on [email protected]

Dr ESEZOBOR CAN AS WELL CURE THE FOLLOWING DISEASE:-

1. HERPES

2. PENIS ENLARGEMENT

3. GONORRHEA

4. HIV/AIDS

5. LOW SPERM COUNT

6. MENOPAUSE DISEASE

7. EPILEPSY

8. ASEPSIS

9. CANCER

10. ANXIETY DEPRESSION

11. PREGNANCY PROBLEM

12. SHORT SIGHTEDNESS PROBLEM

13.YOU NEED YOUR WIFE OR HUSBAND BACRK

14. PTSD

15 ADHD,..............
jame mary
|
June 03, 2020
All these post about HERBAL MEDICINE,are scarms and fake

trying to collect money all in the name of HERPES cure and when you contact them they will be asking for your name, pictures, country, phone number,

occupation and when you have given them all the information, they will be

asking for money. my name is jame mary,from Palm coast Florida U.S.A,

a woman of 56years I was once

suffering from herpes for good 3years and i spent a

lot of money going from one herbal doctor to another but they all scam and

take my money away until i told my friend the problems am facing in life he

quickly introduce me to this powerful herbal man called

Dr.ESEZOBOR who cured me from Herpes with his herbal medication , after

Doctor ESEZOBOR has finished preparing the herbal medicine, he asked me to

send him my residential address, so that he will send the herbal medicine

to me via D.H.L so i did. 2days later, i received the herbal medicine and i

had to follow the instructions he gave to me on how i will apply it. After

using if for a week and few days and I noticed that all the symptoms, pain,

itch and blisters are gone. 2weeks

later i went to hospital for test and according to the test done by the

Medical doctor called Marly it stated that i was herpes negative.

So viewers be wise and beware of fake people and fake herbal

doctors, they are all over the internet trying to steal from poor people. I

will drop the email of this powerful herbal doctor just in case you

want to contact him for help,WHATSAPP HIM ON 18327287363 or Email him on [email protected]

Dr ESEZOBOR CAN AS WELL CURE THE FOLLOWING DISEASE:-

1. HERPES

2. PENIS ENLARGEMENT

3. GONORRHEA

4. HIV/AIDS

5. LOW SPERM COUNT

6. MENOPAUSE DISEASE

7. EPILEPSY

8. ASEPSIS

9. CANCER

10. ANXIETY DEPRESSION

11. PREGNANCY PROBLEM

12. SHORT SIGHTEDNESS PROBLEM

13.YOU NEED YOUR WIFE OR HUSBAND BACRK

14. PTSD

15 ADHD...
statonaaaaaaaa
|
June 03, 2020
I'm here to testify about the great work Dr Osebor did for me. I have been suffering from (HERPES) disease for the past 5

years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed

someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago

i came across a testimony of one lady on the internet testifying about a Man called Dr Osebor on how he cured her from

HIV Virus. And she also gave the email address of this man and advise anybody to contact Dr Osebor for help for any kind

of sickness that he would be of help, so I emailed him on ( [email protected] ) telling him about my (HERPES

Virus) he told me not to worry that i was going to be cured!! Well i never believed it,, well after all the procedures

and remedy given to ame by this man few weeks later i started experiencing changes all over me as Dr Osebor assured me

that i will be cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So

friends my advise is if you have such sickness or any other at all you can contact Dr Osebor via email. {

[email protected] }or call or what sapp him on( 2348073245515 )

DR osebor CAN AS WELL CURE THE FOLLOWING DISEASE:-

 HIV/AIDS

 HERPES

CANCER

ALS

cancer

eye problem etc.

ALEX LENA
|
June 03, 2020
had my first outbreak of oral Herpes nearly

4 years ago. Of all the horribleness, the

pain and itching were unbearable. I literally

freaked out as my general physician said

that it had no cure. The outbreaks were

not that frequent initially, but every time

Id fall sick, it would resurface. I had so

many sores last year that I was desperate

to try anything to get rid of them. 6 months

ago a friend suggested that I try Dr isaac

herbal remedies, I did really ordered

the product and started using it. I'm so

relieved to say that I've not had even one

outbreak and I was tested negative by my

doctor. I'm feeling great from within.I

truly endorse this product, it really works.

You can contact him on email [email protected] or WhatsApp

2347052019211..
Jacob mason
|
June 03, 2020
FINALLY FREE FROM HERPES VIRUSI thought my life had nothing to offer anymore because life became meaningless to me because I had herpes virus, the symptoms became very severe and bold and made my family run from and abandoned me so they won't get infected. I gave up everything, my hope, dreams,vision and job because the doctor told me there's no cure. I consumed so many drugs but they never cured me but hid the symptoms inside me making it worse. I was doing some research online someday when I came across testimonies of some people of how DR ADIGBA cured them from herpes, I never believed at first and thought it was a joke but later decided to contact him on the details provided and when I messaged him we talked and he sent me his herbal medicine and told me to go for a test after two weeks. Within 7 days of medication the symptoms disappeared and when I went for a test Lo and behold I was NEGATIVE by the Doctor Who tested me earlier. Thank you DR ADIGBA because I forever owe you my life and I'll keep on telling the world about you. If you are going through same situation worry no more and contact DR ADIGBA via [email protected] com or WhatsApp him via 2348077875210. he is good too to cure all type of disease and virus. 1 HIV cure 2 cancer 3 diabetes 4 hepatitis 5 herpes. You can contact if you are having any problem... 
Amanda Bella
|
June 03, 2020
I Want To Appreciate Dr.OYAGU for his great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And i Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have The Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:[email protected]

Or Cell Whatsapp Number 2348101755322 thank you
Alika
|
June 03, 2020
I AM Justina from Australia, Thanks to Dr Alika for the special and marvelous work he did for me, i was suffering from Cancer for more than 2 years, i have tried several drugs but no cure, until the day i was searching the Internet for help, i come across a testimony of a woman who said that Dr Alika has cure her of her Cancer at 1st i thought it was a joke and scam but i said let me just contact him, that was how i contacted and he told me not to worry that i should have faith that i will be heal after using his herbal medicine, so he told me what to do and i did it, he gave me his herbal medicine and directed me of how i will be using the medicine, i did everything he told me, after 2 weeks i went to the hospital to do some check up to my greatest surprise all my sickness are gone, i don't really know how i will appreciate this man but i will keep sharing what he did for me to the world till i die. so anyone that is in need of his herbal medicine should contact him now on his email address: [email protected], i am telling you this because he has cure my sickness. once more i want to say a very Big thanks to you Dr Alika actually you are really a solution to all problems. my people out there who is suffering from any sickness there is no time to waste hurry up and contact him by email: [email protected] or Whatsapp: 35677926593.
Mtungwa joy
|
June 03, 2020
Hello brothers and sister i am so glad to writing this article today to tell the world how Dr OYAKHIRE cured my HSV VIRUS,i have been detected with HSV-1 AND HSV-2 since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn’t cure my HSV VIRUS neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr OYAKHIRE the powerful herbalist that cure numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his email: [email protected] i explained everything to him and prepared a cure that cure my HSV-1 AND HSV-2 disease totally after receiving his herbal medicine, so my friends viewers why wait and be suffer when there is someone like Dr.OYAKHIRE that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS, you can contact his via:[email protected] or watsapp 2347084100646
jennifer marry
|
June 03, 2020
Hello brothers and sister i am so glad to writing this article today to tell the world how Dr OYAKHIRE cured my HSV VIRUS,i have been detected with HSV-1 AND HSV-2 since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn’t cure my HSV VIRUS neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr OYAKHIRE the powerful herbalist that cure numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his email: [email protected] i explained everything to him and prepared a cure that cure my HSV-1 AND HSV-2 disease totally after receiving his herbal medicine, so my friends viewers why wait and be suffer when there is someone like Dr.OYAKHIRE that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS, you can contact his via:[email protected] or watsapp 2347084100646
Amanda Bella
|
June 03, 2020
I Want To Appreciate Dr.OYAGU for his great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And i Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have The Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:[email protected]

Or Cell Whatsapp Number 2348101755322 thank you
roma eva
|
June 03, 2020
Human PapilomaVirus (HPV) Cure Found By Dr Sayo If you're wondering why am here or why am doing this!, i just want to show appreciation to God, and i want other persons who is suffering from this deadly illness, ( Herpes, Coronary Artery Disease (Ischemic Heart Disease), Hiv/AID, Stroke, Trachea, Bronchus, and Lung Cancers, Diarrhea Diseases, Diabetes Mellitus, Dengue, Rota-virus, Other STD and others ) maybe because of ignorance. if you see this don't ignore, i was a victim of hpv, some one introduced him to me, i wrote him, told him what i was going through,  i was not too sure he could help, because i seen other persons, or post but no good outcome, he told me he could help, like others, i got the medicine or the herb whatever you may want to call it, he didn't even charge me a lot, to God i didn't want to use it, but i did, to God be the glory am the one sending this post today in good health and sound mind, ..smile.. i seek for him, i didn't mind the distance so i could show appreciation, i meet with Dr Sayo he didn't ask for anything, all he said is, 'It's God doing. I saw him treat people with different situation and problem maybe worse than yours, tell others. so am telling you today, don't ignore this, if you see this post, tell the next person who you think might need this. contact him,on email ([email protected])
mary vernon
|
June 02, 2020
I am excited to share this testimony, I was 3 years ago diagnosed of  Herpes virus . My medical condition was heart broken because it was causing me so many our brakes, I was subjected to different medications by my medical doctor just to control the ourbrakes. Despite my visit to several doctors my health wasn't getting better, all they could say is for me to stay on the treatment. At the verge of giving up, I went to the internet to search for a treatment on my own at least. But I found a cure instead. In the internet, I read a testimony of a lady who had herpes. She shared an e-mail address of the Doctor. Luckily everything seemed to be okay after I took the Herbal Medicine. I wish I could say that’s the end of it because I haven't had any symptoms since then.  Do not expose yourself to more danger, use a herbal remedy that is safe and effective. If interested contact him via email address [email protected] or call  2348107155060  
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