$15M grant funds UCSD research on new vaccine effort to prevent strep throat
Published - 09/11/19 - 07:00 AM | 2879 views | 16 16 comments | 44 44 recommendations | email to a friend | print

CARB-X — an international non-profit partnership of private, academic and government institutions — recently awarded a Northern California-based biopharmaceutical company with a grant up to $15 million. The company, SutroVax, Inc., will use the money to develop a universal vaccine for Group A Streptococcus (GAS), the bacteria that causes pharyngitis or strep throat.

The novel effort is based upon original research by scientists at the University of California San Diego School of Medicine, who will collaborate on vaccine development and conduct initial testing.  

Each year, there are more than 600 million cases worldwide of pharyngitis, an infection, and inflammation of the pharynx (the membrane-lined cavity at the back of the throat). The condition is highly contagious and prevalent among school-age children. 

While typically causing only minor illness, GAS can also pose a serious health threat. When it invades the bloodstream or deeper tissues, GAS can produce severe infections, such as sepsis, necrotizing fasciitis (flesh-eating disease), and toxic shock syndrome. GAS is also the trigger for post-infectious immune-mediated rheumatic heart disease, which kills more than 300,000 people annually. 

Currently, there is no safe, efficacious commercial vaccine against GAS.

The GAS vaccine development program is based upon published research by Victor Nizet, MD, professor of pediatrics and pharmacy at UC San Diego School of Medicine, Nina van Sorge, PharmD, PhD, a former post-doctoral fellow in Nizet's lab and now associate professor at Utrecht University Medical Center in the Netherlands, and colleagues.

In 2014, Nizet, van Sorge and collaborators identified the genes encoding a molecule that famously defines GAS. The findings shed new light on how strep bacteria resists the human immune system and provide a new strategy for a vaccine. The patented discoveries were licensed to SutroVax, a biotech firm located in Foster City, Ca. that specializes in novel complex antigen-based vaccines.

Efforts to develop a GAS vaccine have been significantly hindered by complexities in how the human immune system reacts to the bacterial pathogen. Specifically, some patients with strep infections produce antibodies that cross-react with their own heart valve tissue, leading to rheumatic heart disease. 

Though rare in the United States, rheumatic fever remains common in some developing countries and causes significant disability and death. An important concern in GAS vaccine development is to avoid selecting bacterial antigens that could inadvertently trigger such an autoimmune reaction in humans. 

Nizet, van Sorge and colleagues believe they found a way to circumvent the damaging autoimmune response triggered by strep. The strep cell wall is primarily composed of a complex molecule known as the group A carbohydrate (GAC) which, in turn, is built from repeating units of the bacterial sugar rhamnose and the human-like sugar N-acetylglucosamine (GlcNAc). 

"Because GAC is universally conserved among all GAS strains and elicits protective antibodies in natural infection, it is an attractive candidate for vaccine development," said Nizet. "The catch has been previous research indicating that GlcNAc sugars present in GAC may be responsible for triggering production of heart-damaging antibodies in some patients. 

"The fundamental advance provided by UC San Diego research was the discovery of the GAS genes that encode the machinery for GAC synthesis, and thus a way to eliminate the pathogen's ability to add GlcNAc sugars on the molecule."  

Funding for the vaccine project is based on development milestones. CARB-X is the world's largest funder of antibacterial development research, with 30 active projects in five countries. Since launching in 2016, it has awarded more than $130.5 million. An effective vaccine against GAS pharyngitis would mean a large reduction in global antibiotic use, alleviating the selective pressure for antibiotic resistance development.

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nicole schram
|
May 30, 2020
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May 27, 2020
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Jose Miracle
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May 01, 2020
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April 30, 2020


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celestine mashal
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April 30, 2020
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March 11, 2020
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Wilfrey
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March 11, 2020
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February 15, 2020
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October 29, 2019
MY HERPES CURE TO NEGATIVE RESULT. take your time to read my review on how i got cured of herpes virus so easily, I am from the United States,  Austin Texas. I usually see my outbreak 3 or 4 weeks , my friend introduced me to a herbal Doctor who cure herpes  virus  and  i witnessed it myself.  (doctor email.. ( [email protected])  it's has been 2 years since I was cured from this virus, no more outbreak , no symptoms of the herpes virus, I am so happy to have met people who have been cured and to have read their testimony, after i complete taking the herbal medication, I went to my doctor to check if I was completely negative, he confirmed  that I am 100% negative of the  herpes virus, it is hard to believe that I was cured of herpes with a herbal medicine by Dr. Mohammed, I was tested negative after using the herbal medication, i went to several lab for blood test and it was the same result, herpes negative, could it be true that I was healed? because I thought there was no cure, I'm so happy with my result today, I feelt  wonderful ,  you can also contact him for you cure . Herbal medicine cure herpes virus completely to 100% negative by doctor confirmation,  I am very healthy and perfect , no outbreak, no pain and my result came out negative after using Dr Mohammed herbal medicine. it is true they say there is no problem with a solution. contact the great doctor for complete cure of any kind of virus and disease, his email address..  [email protected] whatsapp / call 2349036036397
Eva Davis
|
October 17, 2019
WHY WILL YOU SAY HERPES SIMPLEX VIRUS 1 & 2 HAS NO CURE WHEN YOU HAVE NOT USE DR HASSAN HERBAL MEDICINE .my name is Eva Davis i'm from UK I was diagnosed of HSV 2 in 2014, i took different kinds of medication still yet no improvement until i saw testimonies of DR HASSAN curing Herpes, Diabetes, HIV/AIDS, CANCER and other disease i was skeptical about contacting him but i also knew the importance of herbal medicine, i made up my mind and contacted him we talked on phone and he prepared and gave me medicine which i took according to his dosage information. Now I’m so happy I’m cured from HSV 2, my heart is so filled with joy, thank you so much DR. HASSAN . If you are reading this and you have Herpes or any kind of disease contact him EMAIL:  [email protected]

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jane22
|
September 14, 2019
I was diagnose with human papilloma virus (HPV) 4 years ago and i met a doctor he told me there is no cure and i have be taking some medication the warts multiplied when trying to removed them and it got me embarrass and pains, luckily few weeks ago i was recommend to Dr bante for natural treatment after one week i got 100% cure and all the wart and pains got disappeared, i sheared this post because its part of my life experience, encase anyone need speedy help about this cure email Dr bante via, [email protected] or whatsapp him on 2349063962262. add on hangout [email protected]

donald sharrel
|
September 12, 2019


my ex boyfriend Peter and I.have been dating for 8 months, and we have been talking about getting married and spending the rest of our lives together. But things started to changed Peter he isn’t willingly to be fully committed relationship and every time we talk about these things with each other he keeps walking away and gets upset about it. also i was heartbroken,Thanks to the internet which has seems to have made everything more easy and possibilities to come out of difficult issues. At first when peter left me i didn’t have any idea on how to restore my relationship back, But through the internet i was able to get the details of this powerful spell caster

called Dr.Noble whose details are:[email protected] Call or WhatsApp: 2348145643630 Whom i contacted and my broken relationship became restored within 11 hours,thanks Dr.
Olivia Jayden
|
September 13, 2019
HOW I GOT MY EX HUSBAND BACK WITH THE HELP OF REAL AND EFFECTIVE SPELL FROM DR Osasu My name is Olivia Jayden, I never thought I will smile again, My husband left me with two kids for one year, All effort to bring him back failed I thought I'm not going to see him again not until I met a lady called Jesse who told me about a spell caster called Dr. Osasu , She gave me his email address and mobile number and I contacted him and he assured me that within 48hours my husband will come back to me, In less than 48hours my husband came back started begging for forgiveness saying it is the devils work, so I'm still surprise till now about this miracle,i couldn't conceive but as soon as the spell was cast,i became pregnant and gave birth to my third child,if you need any assistance from him you can contact him via:email: [email protected] Or WhatsApp or call him now:

Website http://Drosasu.com.ng 2347064365391 . Dr.Osasu also cures: 1. HIV / AIDS 2. HERPES 1/2 3. CANCER 4. ALS (Lou Gehrig’s disease) 5. Hepatitis B

Elizabeth Nathaniel
|
September 11, 2019
There is A cure for Herpes virus

I was tested Herpes positive in 2018 which I have been searching for cure from different doctor until I came across a testimony of Gabby Gabriel on a blogger who said she was cured from 2 years Genital Herpes with Herbal medicine and she included the doctors email which name is doctor Ahmed Usman, I contacted him and he replied and after much discussion he sent his Herbal medicine to me which I took for 21 days with his prescription. I discovered that I no longer have frequent fever and headaches and the sores on my genital parts were healed, after concluding the Herbal medication I went for test and my PCR DNA result was Negative, there was no trace of the virus on my blood thanks to doctor Ahmed for his cure. Contact him on [email protected], I recommend him for Herpes or any diseases. He has Herbal cure for the following diseases; Heart Diseases, Cancer, Fibroid, HIV, Autism and Typhoid
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