$15M grant funds UCSD research on new vaccine effort to prevent strep throat
Published - 09/11/19 - 07:00 AM | 2879 views | 16 16 comments | 44 44 recommendations | email to a friend | print

CARB-X — an international non-profit partnership of private, academic and government institutions — recently awarded a Northern California-based biopharmaceutical company with a grant up to $15 million. The company, SutroVax, Inc., will use the money to develop a universal vaccine for Group A Streptococcus (GAS), the bacteria that causes pharyngitis or strep throat.

The novel effort is based upon original research by scientists at the University of California San Diego School of Medicine, who will collaborate on vaccine development and conduct initial testing.  

Each year, there are more than 600 million cases worldwide of pharyngitis, an infection, and inflammation of the pharynx (the membrane-lined cavity at the back of the throat). The condition is highly contagious and prevalent among school-age children. 

While typically causing only minor illness, GAS can also pose a serious health threat. When it invades the bloodstream or deeper tissues, GAS can produce severe infections, such as sepsis, necrotizing fasciitis (flesh-eating disease), and toxic shock syndrome. GAS is also the trigger for post-infectious immune-mediated rheumatic heart disease, which kills more than 300,000 people annually. 

Currently, there is no safe, efficacious commercial vaccine against GAS.

The GAS vaccine development program is based upon published research by Victor Nizet, MD, professor of pediatrics and pharmacy at UC San Diego School of Medicine, Nina van Sorge, PharmD, PhD, a former post-doctoral fellow in Nizet's lab and now associate professor at Utrecht University Medical Center in the Netherlands, and colleagues.

In 2014, Nizet, van Sorge and collaborators identified the genes encoding a molecule that famously defines GAS. The findings shed new light on how strep bacteria resists the human immune system and provide a new strategy for a vaccine. The patented discoveries were licensed to SutroVax, a biotech firm located in Foster City, Ca. that specializes in novel complex antigen-based vaccines.

Efforts to develop a GAS vaccine have been significantly hindered by complexities in how the human immune system reacts to the bacterial pathogen. Specifically, some patients with strep infections produce antibodies that cross-react with their own heart valve tissue, leading to rheumatic heart disease. 

Though rare in the United States, rheumatic fever remains common in some developing countries and causes significant disability and death. An important concern in GAS vaccine development is to avoid selecting bacterial antigens that could inadvertently trigger such an autoimmune reaction in humans. 

Nizet, van Sorge and colleagues believe they found a way to circumvent the damaging autoimmune response triggered by strep. The strep cell wall is primarily composed of a complex molecule known as the group A carbohydrate (GAC) which, in turn, is built from repeating units of the bacterial sugar rhamnose and the human-like sugar N-acetylglucosamine (GlcNAc). 

"Because GAC is universally conserved among all GAS strains and elicits protective antibodies in natural infection, it is an attractive candidate for vaccine development," said Nizet. "The catch has been previous research indicating that GlcNAc sugars present in GAC may be responsible for triggering production of heart-damaging antibodies in some patients. 

"The fundamental advance provided by UC San Diego research was the discovery of the GAS genes that encode the machinery for GAC synthesis, and thus a way to eliminate the pathogen's ability to add GlcNAc sugars on the molecule."  

Funding for the vaccine project is based on development milestones. CARB-X is the world's largest funder of antibacterial development research, with 30 active projects in five countries. Since launching in 2016, it has awarded more than $130.5 million. An effective vaccine against GAS pharyngitis would mean a large reduction in global antibiotic use, alleviating the selective pressure for antibiotic resistance development.

Comments-icon Post a Comment
nicole schram
May 30, 2020
I had my first outbreak of Herpes virus nearly 4 years ago. Of all the horridness, the pain and itching were unbearable. I literally freaked out as my general physician said that it had no cure. The outbreaks were not that frequent initially, but every time I fall sick, it would resurface. I had so many sores this year that I was desperate to try anything to get rid of them. Three months ago a friend suggested that I try Dr sikama remedy that's helping people get cured from HSV, COUGHING, HIV&AIDS, GENITAL HERPES, SNEEZING, HEPATITIS B, CANCER e.t.c. I quickly ordered the product and started using the remedies. I'm so relieved to say that I've not had even one outbreak for a whole month now. Moreover, I'm feeling great from within. I truly endorse this herbs product Dr sikama render to me. So if you are suffering from any deadly disease you can also contact this great man on his email: [email protected] call/WhatsApp: 2348130725051    
May 29, 2020
How I  Permanently got cured from HPV.........  Giving up on finding a Solution to HPV was Something I never Imagined, When i First got Diagnosed The Doctor Told Me There is no Cure To this Virus I Felt like the world crumbled upon me, but I had Courage and kept on going and Living with it.. I knew Someday Somewhere there Would be a possible permanent Solution to this virus.   I was tired of Uncontrollable Warts and Sores in my Genitals and skin Even in my Anus, I kept on applying creams and Gels when having This  Warts but it never helped.   I was Searching Through online forums and I found on a Blog Where Everyone Shares Their Experiences with This Virus and i Saw People Testified of Been Cured From HPV Through (Best DR. Alabi) Medical Herbs. I Searched For More information about this Dr. and I found out he cures this HPV and HERPES with Natural Herbs, I took his email [email protected] Which I use to order this Remedies and it was sent to me in my Home in 3 days After he asked Me to send Him my Home Address.   I took this Medicines For 3 Weeks and I Had my First Test in Which My Dr. took some samples from me and it surprisingly Reported Negative, I had Another Appointment with the Doctor after 2 Months and the Test Results Still came Out Negative. I can't thank Dr. Alabi Enough for Restoring back my life.


Email>     [email protected]>    2348155011610
May 27, 2020
ALL THANKS TO BEST DR. ALABI WITH HIS HERBAL MEDICINES MY WIFE WAS COMPLETELY CURED FROM MULTIPLE FIBROID.    It Is my pleasure to comment on this site this is one of the happiest moment of my life to see my wife put to birth. This Awesome Moments makes you a man, I really don't know how to thank DR. ALABI for helping my wife get cured from years of MULTIPLE FIBROID.   I came across DR ALABI  Number  2348155011610  Through a Headline News on the internet about how DR ALABI helped a woman to get cured From Fibroid and so many other with similar body problem, i contacted him and he told me how to get this Herbs, few day later he sent me the Herbal portion Through UPS Courier Delivery service and i got his herbs in my Home within 4 days, which my wife Took every Day for 19 days, and this herbal medicines was able to Shrink My Wife from this  Fibroid Naturally,and now my wife is 7 months Pregnant for our second child, and now she is very okay without No Side Effects whatsoever, If you have any Type of Fibroid, you can also contact him on his Email: address> [email protected]  or Call/ WhatsApp Him on 2348155011610
Clifford john
May 27, 2020
Hello everyone out there. Dr. OGODO Herbal Medicine is a good remedy for #Herpes #Virus , I was a carrier of Herpes and I saw a testimony on how Dr. OGODO cure Herpes Virus, I decided to contact him, I contacted him and he guided me. I asked him for solutions and he started the remedies for my health. After he finish he sent me the herbs which i took for 2 weeks before asking me to go for a check up and getting there i could not believe that i was confirm #Herpes Negative after the test,Today i am so happy because i'm free from herpes disease with the help of Dr. OGODO Thank God now everything is fine, I'm cured by Dr. OGODO herbal medicine, I'm very thankful to God for making it possible. you can reach him on his email, i strongly recommend him to any one out here looking for a cure . [email protected]}.

You can also reach him through this WhatsApp number 2349044680467

He also specializes on treating different kinds of diseases such as




*kidney problem


*Low sperm count

*Stroke/Infection all over the body E.t.c

Jose Miracle
May 01, 2020
I have a wonderful testimony to share to the whole world on how Papa Egbe used his herbal product on me, I have been affected with HPV for 6 years and I might papa Egbe through a testimony shared by someone online and told my self let me give him a try and visiting many hospitals and herb home for cure and so lucky for me he did a wonderful job on me and the virus I have had for 6 years was completely cured, thank to Papa Egbe for making me healthy again. What are you infected with=

Hepatitis ABC.

Hiv and aids.

Hsv 1&2.


Cancer of any kinds.


Genital wart.

Kidney Disease.

Heart disease.

Relationships and marriage problems.

Contact him now for a cure via email papaegbespiritualtemple @ gmail. com or via WhatsApp 234 813 495 9928, with your infection listed and not listed, for Natural Remedies.
Harris Ben
April 30, 2020

The doctors said Herpes virus do not have medical cure because the virus is capable of hiding within the human cells, it remains protected from your immune system. Herpes isn’t a special virus – your immune system has the tools to fight it back. But because it is able to lay dormant in protected cells, your immune system is unable to remove it from your body,But with strong reactive herbal medication is capable of getting rid of the virus gradually and totally from your body without damaging any of your cells,natural herbs kills the virus totally not just reducing the out break. Get natural herbs cure from Dr. Agbomina or reach him through his email: [email protected] or whatsapp no: 2349039139161....

celestine mashal
April 30, 2020
ALL THANKS TO DR MUSTAFA WITH HIS HERB MY WIFE WAS COMPLETELY CURED FROM FIBROID.Is my pleasure to comment on this site and i thank the admin of this site for his/her great work so far.one of the happiest moment in life is when you see your own wife put to bed.this awesome moments makes you a man, I really don't know how to thank DR MUSTAFA for helping my wife get cured for over how many year of suffering from FIBROID. i came across DR MUSTAFA contact through a headline news on internet about how DR MUSTAFA help a woman to get cured of his fibroid and so many other with similar body problem ,i contacted him and he told me how to get his herb,few day later he sent me the herbal portion which my wife take every morning for 21 days, and his medicine was able to shrike the fibroid naturally,and now my wife is 5 months old pregnant for our second child, and now she very okay without any side effects whatsoever, If you have fibroid, you can contact him on his Email: address, [email protected]  or on WhatsApp add plus  2347010821863 for advice and for his product
March 11, 2020
Hello, I want to write a little review about the good work of doctor Solution who cured me from HSV 1 and 2 for just 2 week with his herbal medicine, I never believe I can be normal again and have a good life like others I always regretted the day I got diagnose with the virus, I was lost of hope when my doctor told me there is no cure for it but I keep thinking and thinking about my future, if I can have kids of my own well I am so grateful for my helper who get me cured with his herbal medicine, I went online in search of anything that can help me because I can’t deal with it forever so I found this doc solution email on a blog of someone who was cured by him I quickly contacted him for help and explained all my pain to him, he told me not to worry about it there is cure for real, I never believe until he sent me the herbal medicine when I ordered for it and I got it within 5 working days that is how I took the medicine for 2 weeks and the following week I went for test just to confirm I was 100% cured from this sickness what a miracle in my life I am so happy right now, you can also get in contact with him if you have such sickness through email address:: [email protected] com
March 11, 2020
Am wilfrey by name, i was diagnosed with Herpes for 6years ago i lived in pain with the knowledge that i wasn't going to ever be well again i contacted so many herbal doctors on this issue and wasted a large sum of money but my condition never got better i was determined to get my life back so one day i saw mr deshant post on how Dr Iyoha saved him from the VIRUS with his herbal medicine i contacted Dr Iyoha on his email address [email protected] we spoke on the issue i told him all that i went through and he told me not to worry that everything will be fine again so he prepared the medicine and send it to me through courier service and told me how to use it, after 2 weeks of usage I went to see the doctor for test ,then the result was negative,am the happiest woman on earth now. this testimony is real.thanks to Dr Iyoha God bless you. you can also reach him on his number: 1 407 337 9869

Dr Iyoha also cure the following

1 cancer cure

2 diabetes cure

3 ringing ear

4 herpes cure

5 warts cure

6 HPV cure


8 get your ex back

9 pregnancy herbal medicine

10 prostate enlargement

11 Hepatitis B

harrison williams
February 15, 2020
GET REAL CURE ON HERPES SIMPLEX VIRUS.  Doctor email that was able to cure my herpes virus.([email protected]) (whatsapp/call 2349036036397)some times we just need to give a try to herbal Medicine to see for our self. I am very happy today that i do not listen to what people say if not i would have been a dead man by now. I was infected with HERPES SIMPLEX VIRUS in 2014, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution out so that my body can be okay. One day I was in the office thinking where I can go to get solution. so a lady walked to me telling me why am I so sad and i open up all to her telling her my problem, she told me that she can help me out, she introduce me to a doctor who uses herbal medication to cure HERPES SIMPLEX VIRUS, HIV, HPV and many more disease and she gave me his email, so i mail him. He told me all the things I need to do and send me the herbal medicine through courier delivering service and also give me instructions to take, which I followed properly. Before I knew what is happening after 3 weeks the HERPES SIMPLEX VIRUS that was in my body got vanished and blister dried off . I went to the hospital for a test and it was negative. this man is real and he is the solution to herpes virus. so if you are also heart broken and also need a help, you can also email him [email protected] (call or whatsapp 2349036036397 according to this great DR he can also cure HIV, ALS,CANCER, COLD SORE, HPV, HEPATITIS OF ALL KIND AND DIABETES    
marvis ven
October 29, 2019
MY HERPES CURE TO NEGATIVE RESULT. take your time to read my review on how i got cured of herpes virus so easily, I am from the United States,  Austin Texas. I usually see my outbreak 3 or 4 weeks , my friend introduced me to a herbal Doctor who cure herpes  virus  and  i witnessed it myself.  (doctor email.. ( [email protected])  it's has been 2 years since I was cured from this virus, no more outbreak , no symptoms of the herpes virus, I am so happy to have met people who have been cured and to have read their testimony, after i complete taking the herbal medication, I went to my doctor to check if I was completely negative, he confirmed  that I am 100% negative of the  herpes virus, it is hard to believe that I was cured of herpes with a herbal medicine by Dr. Mohammed, I was tested negative after using the herbal medication, i went to several lab for blood test and it was the same result, herpes negative, could it be true that I was healed? because I thought there was no cure, I'm so happy with my result today, I feelt  wonderful ,  you can also contact him for you cure . Herbal medicine cure herpes virus completely to 100% negative by doctor confirmation,  I am very healthy and perfect , no outbreak, no pain and my result came out negative after using Dr Mohammed herbal medicine. it is true they say there is no problem with a solution. contact the great doctor for complete cure of any kind of virus and disease, his email address..  [email protected] whatsapp / call 2349036036397
Eva Davis
October 17, 2019
WHY WILL YOU SAY HERPES SIMPLEX VIRUS 1 & 2 HAS NO CURE WHEN YOU HAVE NOT USE DR HASSAN HERBAL MEDICINE .my name is Eva Davis i'm from UK I was diagnosed of HSV 2 in 2014, i took different kinds of medication still yet no improvement until i saw testimonies of DR HASSAN curing Herpes, Diabetes, HIV/AIDS, CANCER and other disease i was skeptical about contacting him but i also knew the importance of herbal medicine, i made up my mind and contacted him we talked on phone and he prepared and gave me medicine which i took according to his dosage information. Now I’m so happy I’m cured from HSV 2, my heart is so filled with joy, thank you so much DR. HASSAN . If you are reading this and you have Herpes or any kind of disease contact him EMAIL:  [email protected]

mobile/WHATSAPp   2349032582239
September 14, 2019
I was diagnose with human papilloma virus (HPV) 4 years ago and i met a doctor he told me there is no cure and i have be taking some medication the warts multiplied when trying to removed them and it got me embarrass and pains, luckily few weeks ago i was recommend to Dr bante for natural treatment after one week i got 100% cure and all the wart and pains got disappeared, i sheared this post because its part of my life experience, encase anyone need speedy help about this cure email Dr bante via, [email protected] or whatsapp him on 2349063962262. add on hangout [email protected]

donald sharrel
September 12, 2019

my ex boyfriend Peter and I.have been dating for 8 months, and we have been talking about getting married and spending the rest of our lives together. But things started to changed Peter he isn’t willingly to be fully committed relationship and every time we talk about these things with each other he keeps walking away and gets upset about it. also i was heartbroken,Thanks to the internet which has seems to have made everything more easy and possibilities to come out of difficult issues. At first when peter left me i didn’t have any idea on how to restore my relationship back, But through the internet i was able to get the details of this powerful spell caster

called Dr.Noble whose details are:[email protected] Call or WhatsApp: 2348145643630 Whom i contacted and my broken relationship became restored within 11 hours,thanks Dr.
Olivia Jayden
September 13, 2019
HOW I GOT MY EX HUSBAND BACK WITH THE HELP OF REAL AND EFFECTIVE SPELL FROM DR Osasu My name is Olivia Jayden, I never thought I will smile again, My husband left me with two kids for one year, All effort to bring him back failed I thought I'm not going to see him again not until I met a lady called Jesse who told me about a spell caster called Dr. Osasu , She gave me his email address and mobile number and I contacted him and he assured me that within 48hours my husband will come back to me, In less than 48hours my husband came back started begging for forgiveness saying it is the devils work, so I'm still surprise till now about this miracle,i couldn't conceive but as soon as the spell was cast,i became pregnant and gave birth to my third child,if you need any assistance from him you can contact him via:email: [email protected] Or WhatsApp or call him now:

Website http://Drosasu.com.ng 2347064365391 . Dr.Osasu also cures: 1. HIV / AIDS 2. HERPES 1/2 3. CANCER 4. ALS (Lou Gehrig’s disease) 5. Hepatitis B

Elizabeth Nathaniel
September 11, 2019
There is A cure for Herpes virus

I was tested Herpes positive in 2018 which I have been searching for cure from different doctor until I came across a testimony of Gabby Gabriel on a blogger who said she was cured from 2 years Genital Herpes with Herbal medicine and she included the doctors email which name is doctor Ahmed Usman, I contacted him and he replied and after much discussion he sent his Herbal medicine to me which I took for 21 days with his prescription. I discovered that I no longer have frequent fever and headaches and the sores on my genital parts were healed, after concluding the Herbal medication I went for test and my PCR DNA result was Negative, there was no trace of the virus on my blood thanks to doctor Ahmed for his cure. Contact him on [email protected], I recommend him for Herpes or any diseases. He has Herbal cure for the following diseases; Heart Diseases, Cancer, Fibroid, HIV, Autism and Typhoid
Comments are back! Simply post the comment (it'll complain about you failing the human test) then simply click on the captcha and then click "Post Comment" again. Comments are also welcome on our Facebook page.