Researches at UCSD Health Sciences identify gene with functional role in aging of eye
Published - 02/04/20 - 09:00 AM | 3367 views | 99 99 comments | 24 24 recommendations | email to a friend | print

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age. In a new paper, published online Jan. 14, 2020 in the journal Aging Cell, researchers at the University of California San Diego School of Medicine say the gene appears to play a key role in age-associated functional and anatomical aging in vivo in mouse retinas, a finding that has direct relevance to age-related eye diseases. 

Specifically, the research team, led by senior author Dorota Skowronska-Krawczyk, Ph.D., assistant professor in the Viterbi Family Department of Ophthalmology at UC San Diego Shiley Eye Institute, found that an age-related decrease in ELOVL2 gene expression was associated with increased DNA methylation of its promoter. Methylation is a simple biochemical process in which groups of carbon and hydrogen atoms are transferred from one substance to another. In the case of DNA, methylation of regulatory regions negatively impacts the expression of the gene. 

When researchers reversed hypermethylation in vivo, they boosted EVOVL2 expression and rescued age-related decline in visual function in mice. “These findings indicate that ELOVL2 actively regulates aging in mouse retina, provides a molecular link between polyunsaturated fatty acids elongation and visual functions, and suggests novel therapeutic strategies for treatment of age-related eye diseases,” wrote the authors.

ELOVL2 is involved in production of long-chain omega-3 and omega-6 polyunsaturated fatty acids, which are used in several crucial biological functions, such as energy production, inflammation response and maintenance of cell membrane integrity. The gene is found in humans as well as mice. 

In particular, ELOVL2 regulates levels of docosahexaenoic acid or DHA, a polyunsaturated omega-3 fatty acid abundantly found in the brain and retina. DHA is associated with a number of beneficial effects. Notably, its presence in photoreceptors in eyes promotes healthy retinal function, protects against damage from bright light or oxidative stress and has been linked to improving a variety of vision conditions, from age-related macular (AMD) degeneration to diabetic eye disease and dry eyes. 

Skowronska-Krawczyk said the work demonstrated for the first time that a “methylation clock” gene had a functional role in the aging of an organ. In this case, the eye. DNA methylation is used throughout the human body, essentially turning biological switches on and off to maximize efficient operation. It has key regulatory roles in the body’s cardiovascular, neurological, reproductive and detoxification systems. 

In recent years, there has been much work and progress in identifying possible biomarkers that predict the biological age (not chronological) of individuals. Such biomarkers would be useful in identifying risk and status of age-related diseases. ELOVL2 is among the genes attracting greatest interest.  

“I have been asked whether I think ELOVL2 is the aging gene,” said Skowronska-Krawczyk. “After thinking about it, it is not unreasonable to think that lower ELOVL2 expression might be at the basis for many age-related conditions. Future work in our lab will address that question.” 

For the full study, visit https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13100

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zAG
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1 Hour Ago
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April 08, 2020
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March 31, 2020
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April 01, 2020
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March 31, 2020
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March 31, 2020
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March 31, 2020
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March 30, 2020
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Susan James
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April 01, 2020
God is Good!I promised God that I would share my testimony on this website. I had all the signs of  STD Virus but I was not too sure as to which one. I did a lot of online research and scared myself straight for a whole week before going to see the nurse. She took one look at my genital part and first said that it could just be the anatomy of my body, then she said it looked like genital warts and that I MAY have herpes. I was devastated. She gave me some medicine for the herpes and some cream for the warts. I was also tested for every single STD including herpes. I went home and cried searching the web for all sorts of cures for herpes and awaiting my results. I saw a post whereby Dr. Kham Blessed cured Herpes and other diseases, I copied his contacts out and added him on whats app via 2348159922297. The next day my test result was ready and i confirmed  Herpes positive. I told Dr. Kham Blessed about my health problems and he assured me of cure. He prepared his herbal medicine and sent it to me. I took it for 14 days (2 weeks). Before the completion of the 14 days in which I completed the dose, the Blisters and Warts that were on my body was cleared. I went back for check-up and I was told I'm free from the virus. Dr. Kham Blessed cures all types of diseases and viruses with the help of his herbal medicine. You can reach Dr. Kham Blessed via his email address on (dr.khamcaregiver@gmail.com) or dr.khamcaregiver@outlook.com  or call him on 2348159922297 and whats app him on same number, but You can Also Visit his website to know more about him at > https://drkhamherbalhealingcenter.wordpress.com/   for more info.
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Mornacy
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March 30, 2020
Hello everyone,i'm Evan mornacy from USA.I want to also use this medium to appreciate Mr Lux and Mrs Anna for coming on the platform to shear their experiences on how they were both cured by Dr Iyoha .I have been online looking for a genuine remedy to my illness of 1 year (Hepatitis B) until i read Mr Lux's and Mrs Anna's post.As we all know these days the truth is rear so i didn't want to believe Mr Lux and Mrs Anna until a second taught asked me to.I contacted Dr Iyoha as directed by Mr Lux and Mrs Anna and follow the procedures and everything worked out in a brief.I thought there was no actual cure for Hepatitis B until a little trial

convinced me.From my further inquiry and experience with Dr Iyoha ,he

has a cure for what so ever health challenging issues such DIABETES, STDS,HERPES,HIV,TUBERCULOSIS,VERTEBRAL

ISSUE,CANCER,DIABETES,ISCHEMIC DISEASES,STROKE,RESPIRATORY

INFECTIONS,PULMONARY DISEASE,ALZHEIMER'S DISEASE,DEHYDRATION,CIRRHOSIS,WEAK ERECTION,WATERY SPERM,PREMATURE EJACULATION,ETC.contact him via: driyohasolutiontemple@yahoo.com or call : 1 407 337 9869...
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March 30, 2020


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...Thanks Dr..

Amy Kendral
|
March 29, 2020
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Amy Kendral
|
March 29, 2020
Am testifying of the miraculous work of a great traditional doctor called  Dr Razor, I have been suffering from Hsv 2 for the past 4 years, but today I am happy that am completely cured from it with the herbal medicine made by  Dr Razor the great healer, I was browsing the Internet searching for help when I came across a testimony shared by one miss kendral on how  Dr Razor cured her from Hsv 2 virus. I quickly contacted him to get the cure and today i am now free from the Virus, Reach out to doctor razor herbs to get yours today Email : drrazorherbalhome@gmail.com Whatsapp or call him on  2349065420442
Susan James
|
April 01, 2020
God is Good!I promised God that I would share my testimony on this website. I had all the signs of  STD Virus but I was not too sure as to which one. I did a lot of online research and scared myself straight for a whole week before going to see the nurse. She took one look at my genital part and first said that it could just be the anatomy of my body, then she said it looked like genital warts and that I MAY have herpes. I was devastated. She gave me some medicine for the herpes and some cream for the warts. I was also tested for every single STD including herpes. I went home and cried searching the web for all sorts of cures for herpes and awaiting my results. I saw a post whereby Dr. Kham Blessed cured Herpes and other diseases, I copied his contacts out and added him on whats app via 2348159922297. The next day my test result was ready and i confirmed  Herpes positive. I told Dr. Kham Blessed about my health problems and he assured me of cure. He prepared his herbal medicine and sent it to me. I took it for 14 days (2 weeks). Before the completion of the 14 days in which I completed the dose, the Blisters and Warts that were on my body was cleared. I went back for check-up and I was told I'm free from the virus. Dr. Kham Blessed cures all types of diseases and viruses with the help of his herbal medicine. You can reach Dr. Kham Blessed via his email address on (dr.khamcaregiver@gmail.com) or dr.khamcaregiver@outlook.com  or call him on 2348159922297 and whats app him on same number, but You can Also Visit his website to know more about him at > https://drkhamherbalhealingcenter.wordpress.com/   for more info.
mofana fistos
|
March 29, 2020
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Andy baldwin
|
March 29, 2020
CURED FROM HERPES VIRUS ...indeed DR MUSTAFA IS a God sent

DR mustafa is the only Dr who could ever get Herpes cured with his healing medicine, i have tried almost everything but i couldn't find any solution on my disease, despite all these happening to me, i always spend a lot to buy drugs from hospital and taking some several medications but no relieve, until one day i was just browsing on the internet when i come across a great post of 'Morrison' who truly said that he was been diagnose with Herpes and was healed the nest week through the help of this great powerful healing doctor, so i quickly contacted him, and he ask me some few questions and he said a thing i will never forget that any one who contacted him is always getting his or her healing ,so i was amazed all the time i heard that from him,so he sent me the herbal medicine ,and after taking his medicine for the period of time he told me to, i noticed a very hug difference in my health,so i went to the hospital to give the final test to the disease and the doctor said i am HERPES NEGATIVE ,i am very amazed about the healing DR MUSTAFA gave to me from the help of his ancient herbs But if you feel like contacting DR MUSTAFA at once you can email him now for your own healing too at Email :herbalremedies21@gmail.com

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Paul Nancy
|
March 28, 2020
I'm here to testify about the great work Dr Tashe did for me. I have been suffering from (HERPES) disease for the past 5 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called Dr Tashe on how he cured her from Herpes Simplex Virus. And she also gave the email address of this man and advise anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES Virus) he told me not to worry that i was going to by this man month later i started experiencing changes all over me as Dr Tashe assured me that i will be cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness you should also contact him so you too will be free contact him via email drtashe@gmail.com You can also call or whatsApp his telephone number on 2348154724883. Thanks once again Dr Tashe.

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